As ssievert says, if you don't need replication across sites, simple is better. For instance, that way you don't need to bother about search affinity, site specific considerations etc.
However, you might want to consider the replication factor. When your environment grows, and your HA requirements with them, it might be more cost-effective to use multi-site clustering. This is because it allows you to set replication within your sites. It can make quite a bit of difference in the amount of storage you need. There is not a rule-of-thumb here, so I would discuss this in detail with your splunk architect.
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