I'm stealing this suggestion that @starcher made in the enterprise-security channel on Slack.
You can make a lookup with the URLs that you want to ignore from the search, then use that lookup to drop them from the correlation search. This requires modifying the correlation search (I'd recommend making a new one from scratch, and disable the default one)
So, for example, the destination field has the URLs you want dropped, leave the correlation search syntax as-is, then append the lookup at the end and dropping anything that doesn't match. Because it's a URL match, it might not be as fuzzy as you want it, but it's a start.
| lookup mywhitelist destination OUTPUTNEW destination AS isFound | where isnull(isFound)
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