Hi kevinp512,
This is a simple Python error code which tells you that Splunk was not able to send the email. That could have many reasons, like firewall blocking, typo in the config or email recipient - do the usual troubleshooting, but more outside of Splunk.
To troubleshoot what happens inside of Splunk take a look at this answer http://answers.splunk.com/answers/141334/unable-to-trigger-alert-from-splunk-name-or-service-not-known-while-sending-mail.html
Hope this helps ...
cheers, MuS
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