A single instance can only run one deployment server at a time.
However, if the specs on the box are high enough and the number of clients is low enough, you could run multiple instances of Splunk on this box, and configure a DS on each of those instances.
This would look similar to this:
Instance 1: /opt/splunkinstance1 Web on 8000, Management running on port 8089
Instance 2: /opt/splunkinstance2 Web on 8001, Management running on port 8090
Clients would connect to the respective server's management port.
A single instance can only run one deployment server at a time.
However, if the specs on the box are high enough and the number of clients is low enough, you could run multiple instances of Splunk on this box, and configure a DS on each of those instances.
This would look similar to this:
Instance 1: /opt/splunkinstance1 Web on 8000, Management running on port 8089
Instance 2: /opt/splunkinstance2 Web on 8001, Management running on port 8090
Clients would connect to the respective server's management port.
Just to add, you can also adjust polling interval to 1hour or more assuming you won't change config frequently. So that your DS can manage at least 2K forwarders.