As in the contents of the PPT or PDF? No, not without some type of intermediary.
Splunk docs might help you with what Splunk can monitor and index:
http://docs.splunk.com/Documentation/Splunk/6.5.2/Data/WhatSplunkcanmonitor
http://docs.splunk.com/Documentation/Splunk/6.5.2/Data/Monitorfilesanddirectories