I had an older version of eStreamer installed, when I try to change to an new FMC it failed.
When I tried to upgrade to the lastest eStreamer 4.6.0 (#3662), I did not see the Set-Up under the Actions
(Shouldn't there be a Set-Up at the front of the options)
I thought maybe it was because it was already configured. I completely remove the app and re-installed clean.
I still don't see the Set-up to allow me to configure the FMC and the cert.
They forgot to update the documentation link in the app descriptions.
I had the same issue and found it in https://community.splunk.com/t5/All-Apps-and-Add-ons/Cisco-eStreamer-eNcore-for-Splunk-Add-On-v4-6-0...