Not much to go on here... Maybe you can provide some more details around what you've tried and what your current data set or query attempts are...
Broadly you can look at these:
If I run a query I get results, then I look over my results. Sometimes I want to filter out certain things from my results. I'd rather filter out my results and to research the index. I don't need to go back to well, I've got what I need, but I just need to filter out a little.
You're looking for a way to persist some search results -- and then further filter them?
There's a few mechanisms for that with Splunk.
I think one is the closest to what you're looking for:
There's likely a few others that also would help.