To reload your endpoints type the following into your browser:
In addition, index-time props and transforms do not require restarts, as long as your indexers are receiving the data from forwarders. That is to say:
Changes to props.conf and transforms.conf on an indexer do not require restarts. In an indexer cluster, changes to props.conf and transforms.conf are automatically reloaded when the peers receive the changes from the master. On a non-clustered indexer, changes to props.conf and transforms.conf require a reload. On either a clustered or non-clustered indexer, once the .conf files have reloaded, the changes take effect after a forwarder auto-LB time period.
Refer this page
If the configurations are effecting index-time (the way splunk index data) operations, then restart is required.
If configurations are effecting search-time operations, then you can perform debug refresh as suggested by @harsmarvania57.
Please refer to this doc for more details.