I had 4.1.8 forwarders running for months against my 6.1.2 indexers without issue. But when I submitted an issue with a 4.n forwarder, Support wouldn't help because of the 4.n version. So I did the upgrade in three steps. 4.2, 5.0, 6.1.2. It was so easy I linked the 3 individual scripts so that one would call the other. The remaining servers were upgraded in minutes. Why wait?