Hi Team/ @Anonymous  I have tried Instrumenting  .Net standalone application with the help of the below reference link  https://docs.appdynamics.com/display/PRO41/Instrument+Windows+Services+and+Standalone+Applications I could load the profiler and was able to see the application under the "Tiers & Nodes" but was unable to get the transaction snapshots or metrics in the appdynamics controller. I see the below error in the AgentLog.txt, 2022-02-10 08:41:24.0104 21836 AppDynamics.Coordinator 1 27 Error MachineAgentManager Metrics Error sending metrics - will requeue for later transmission Exception: com.appdynamics.ee.agent.commonservices.metricgeneration.metrics.MetricSendException: System.Exception: Failed to execute request to endpoint [https://****************.saas.appdynamics.com:443/controller/instance/76787/metrics_PB_]. For more details if needed please set trace level for logger [com.appdynamics.REST.RESTProtobufCommunicator] ---> System.Net.WebException: The underlying connection was closed: An unexpected error occurred on a send. ---> System.IO.IOException: The handshake failed due to an unexpected packet format. at System.Net.Security.SslState.StartReadFrame(Byte[] buffer, Int32 readBytes, AsyncProtocolRequest asyncRequest) at System.Net.Security.SslState.StartReceiveBlob(Byte[] buffer, AsyncProtocolRequest asyncRequest) at System.Net.Security.SslState.CheckCompletionBeforeNextReceive(ProtocolToken message, AsyncProtocolRequest asyncRequest) at System.Net.Security.SslState.ForceAuthentication(Boolean receiveFirst, Byte[] buffer, AsyncProtocolRequest asyncRequest) at System.Net.Security.SslState.ProcessAuthentication(LazyAsyncResult lazyResult) at System.Threading.ExecutionContext.RunInternal(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx) at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx) at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state) at System.Net.TlsStream.ProcessAuthentication(LazyAsyncResult result) at System.Net.TlsStream.Write(Byte[] buffer, Int32 offset, Int32 size) at System.Net.PooledStream.Write(Byte[] buffer, Int32 offset, Int32 size) at System.Net.ConnectStream.WriteHeaders(Boolean async) --- End of inner exception stack trace --- Note: I can get metrics for the .Net applications deployed in the IIS  Please look into this issue and help us to resolve this. Thanks in advance ... View more